Hydrochloric Acid → HCID 19385508, compound

HRID 2399379Notes

Reaction equation

HRID 2399379 reaction equation
[Cl:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][Cl:10])=[CH:5][CH:4]=1.[CH3:11][CH:12]([O:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[N:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1)[CH3:13].C(N(CC)CC)C.Cl>CCOCC.C1COCC1>[ClH:1].[CH3:13][CH:12]([O:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[N:21]1[CH2:22][CH2:23][N:24]([CH2:2][C:3]2[CH:8]=[CH:7][C:6]([CH2:9][Cl:10])=[CH:5][CH:4]=2)[CH2:25][CH2:26]1)[CH3:11]

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 8471TriethylamineHCID 12171alpha,alpha'-Dichloro-p-xyleneHCID 109440161-[2-(Propan-2-yloxy)phenyl]piperazine

Product 1

HCID 19385508HCID 19385508, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 8028TetrahydrofuranSolvent

Procedure

A solution of α,α'-dichoro-p-xylene(30.40 g ,0.174 mol), N-[2-(1-methylethoxy)phenyl]piperazine (12.70 g, 0.058 mol), triethylamine (6.08 g, 0.06 mol), and THF (200 mL) was refluxed for 4 h. Ether (100 mL) and 1N HCl (100 mL) were added producing a white suspension which was filtered to give 4-[[1-[2-(1-methylethoxy)phenyl]-4-piperazinyl]methyl]benzyl chloride hydrochloride.

Workup

  1. customproducing a white suspension which
  2. filtrationwas filtered

Sources & evidence

ORD record
ord-97e14bf1f93b4bd9b3c8042064712c8b
Source dataset
uspto-grants-1995_09
Patent number
US05449677

Reaction notes

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