Potassium Carbonate → HCID 50988182, compound

HRID 2408400Notes

Reaction equation

HRID 2408400 reaction equation
[CH3:1][C:2]1[O:6][N:5]=[C:4]([CH2:7][O:8][C:9]2[CH:14]=[CH:13][C:12]([N+:15]([O-])=O)=[CH:11][CH:10]=2)[N:3]=1.S(=O)(=O)(O)[O-].[Na+].C(=O)(O)[O-].[Na+].C([O-])([O-])=O.[K+].[K+]>C1COCC1.O>[CH3:1][C:2]1[O:6][N:5]=[C:4]([CH2:7][O:8][C:9]2[CH:14]=[CH:13][C:12]([NH2:15])=[CH:11][CH:10]=2)[N:3]=1

Participants

7

Reactant 4

HCID 11430Potassium CarbonateHCID 516892Sodium BicarbonateHCID 516919Sodium BisulfateHCID 47125109HCID 47125109, compound

Product 1

HCID 50988182HCID 50988182, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolvent2×HCID 8028TetrahydrofuranSolvent

Procedure

O-(5-Methyl-1,2,4-oxadiazol-3-yl)methyl-4-nitrophenol (1 g) was dissolved in THF (40 mL) and water (40 mL). Sodium bisulfate (3.8 g), sodium bicarbonate (1.4 g), K2CO3 (1.8 g) were added to the solution. It was stirred at rt for 30 min, then diluted with water (80 mL). The aq. solution was extracted with EtOAc (2×100 mL). The organic layers were combined, dried, evaporated to give 4-(5-methyl-1,2,4-oxadiazol-3-yl)methoxyaniline.

Workup

  1. extractionThe aq. solution was extracted with EtOAc (2×100 mL)
  2. customdried
  3. customevaporated

Sources & evidence

ORD record
ord-051058da09f749589eb090b8fe2f2ae5
Source dataset
uspto-grants-2014_08
Patent number
US08815848B2

Reaction notes

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