Triethylamine → HCID 22645183, compound

HRID 2414414Notes

Reaction equation

HRID 2414414 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:9])[C:7]=1Cl.[NH:10]1[CH2:15][CH2:14][CH:13]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[CH2:12][CH2:11]1.C(N(CC)CC)C.C(OCC)(=O)C>C1(C)C(C)=CC=CC=1>[Cl:9][C:6]1[CH:5]=[N:4][CH:3]=[C:2]([Cl:1])[C:7]=1[N:10]1[CH2:15][CH2:14][CH:13]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[CH2:12][CH2:11]1

Participants

6

Reactant 4

HCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 70770Ethyl 4-piperidinecarboxylateHCID 37865313,4,5-Trichloropyridine

Product 1

HCID 22645183HCID 22645183, compound

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

2.0 g (11 mmol) of 3,4,5-trichloropyridine, 1.7 g (11 mmol) of ethyl piperidine-4-carboxylate and 4.6 ml (33 mmol) of triethylamine were stirred in 20 ml of xylene under heating under reflux for 10 hours. After the treatment with ethyl acetate as the extraction solvent in an ordinary manner, the obtained crude product was purified by the silica gel column chromatography to obtain the title compound.

Workup

  1. temperatureunder heating
  2. temperatureunder reflux for 10 hours
  3. customwas purified by the silica gel column chromatography

Sources & evidence

ORD record
ord-6c22382d542841828f9bb5b629b18597
Source dataset
uspto-grants-2004_11
Patent number
US06812231B2

Reaction notes

Loading…