Dimethylformamide → 9-Formyl-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocycloheptene-4-carboxylic Acid Methyl Ester

HRID 2415792Notes

Reaction equation

C(=O)([O-])[O-].[K+].[K+].[CH3:7][O:8][C:9](=[O:20])[C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([NH:16][CH:17]=[O:18])[C:11]=1[OH:19].CN(C=O)C.Br[CH2:27][CH2:28][CH2:29]Cl>O.C(OCC)(=O)C>[CH3:7][O:8][C:9]([C:10]1[C:11]2[O:19][CH2:29][CH2:28][CH2:27][N:16]([CH:17]=[O:18])[C:12]=2[CH:13]=[CH:14][CH:15]=1)=[O:20]

Participants

Conditions

Temperature: 120 °C

Procedure

Potassium carbonate was ground and flame dried prior to each use. 3-formylamino-2-hydroxy-benzoic acid methyl ester compound (1.952 grams, 10 mmol) and potassium carbonate (2.764 grams, 20 mmol, 2 eq.) were placed in a flask together with 100 mL of anhydrous DMF. Heated to 120° C. for 1 hour. 1-bromo-3-chloropropane (1 mL, 10 mmol, 1 eq.) was added to the reaction mixture in several portions at 120° C. and the reaction heated for an additional 3 hours. The reaction was monitored on TLC (ethyl acetate). After cooling, the reaction mixture was stripped to a minimal volume, diluted with water and extracted three times with ethyl acetate. The combined organic portions were washed with water, brine and dried over magnesium sulfate. Filtration and solvent removal afforded crude product as a thick brown syrup (1.78 grams) which was chromatographed on silica gel using 30% ethyl acetate in hexane as eluent. The product was obtained in 67% yield as light yellow solid. M+236.

Workup

temperatureflame
customdried
temperaturethe reaction heated for an additional 3 hours
temperatureAfter cooling
extractionextracted three times with ethyl acetate
washThe combined organic portions were washed with water, brine
dry with materialdried over magnesium sulfate
filtrationFiltration and solvent removal

Sources & evidence

ORD record: ord-36f0ca6bd6b34b8bbda7772f42ca4ad5
Source dataset: uspto-grants-2004_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06821977B2

Reaction notes

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