Hydrogen Bromide → HCID 22631312, compound

HRID 2416573Notes

Reaction equation

HRID 2416573 reaction equation
C[O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[CH:8][N:9]=[CH:10]2)=[CH:5][CH:4]=1.[NH2-:13].[Na+].C(OCC)(=O)C.[BrH:21]>C1(C)C(C)=CC=CC=1>[BrH:21].[NH2:13][C:10]1[C:11]2[C:6](=[CH:5][CH:4]=[C:3]([OH:2])[CH:12]=2)[CH:7]=[CH:8][N:9]=1

Participants

6

Reactant 4

HCID 260Hydrogen BromideHCID 8857Ethyl AcetateHCID 24533Sodium amideHCID 5943757-Methoxyisoquinoline

Product 1

HCID 22631312HCID 22631312, compound

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Conditions

Temperature
140 °C

Procedure

5.6 g (35.2 mmol) of 7-methoxyisoquinoline was dissolved in 200 ml of xylene. 26.6 ml (176 mmol) of N,N,N′,N′-tetramethylenediamine and 7.28 g (186 mmol) of sodium amide were added to the obtained solution, and they were stirred at 140° C. for 1 hour. After the treatment with ethyl acetate as the extracting solvent in an ordinary manner, 50 ml of hydrobromic acid was added to the obtained crude product and they were stirred at 140° C. overnight. The solvent was evaporated to obtain the title compound.

Workup

  1. customobtained crude product and they
  2. stirringwere stirred at 140° C. overnight
  3. customThe solvent was evaporated

Sources & evidence

ORD record
ord-76c78ed82a0140428a57601dd43e3d4f
Source dataset
uspto-grants-2004_11
Patent number
US06825181B1

Reaction notes

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