反应详情

To a suspension of 2-(tert-butoxycarbonylamino)acetic acid (16.3 g) and 1-(4-chlorophenyl)piperazine hydrochloride (21.7 g) in N,N-dimethylformamide (200 ml) were added 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (19.6 g) and N-hydroxybenzotriazole (13.8 g) at 0° C. To this suspension was added dropwise triethylamine (10.4 g). The mixture was stirred at room temperature for 20 hours. The reaction mixture was poured into ice-cold water and the resulting solid was collected by filtration. The solid was washed successively with saturated aqueous sodium hydrogencarbonate solution and water. The solid was dried to give the title compound (29 g).

1. additionThe reaction mixture was poured into ice-cold water
2. filtrationthe resulting solid was collected by filtration
3. washThe solid was washed successively with saturated aqueous sodium hydrogencarbonate solution and water
4. customThe solid was dried