反应详情

To a solution of methyl 6-chloro-5-nitronicotinate (3 g, 13.85 mmol) in THF (60 mL) and DMF (30.0 mL) was added ethyl 2-hydroxyacetate (1.573 mL, 16.62 mmol) and potassium carbonate (5.74 g, 41.6 mmol). The reaction was stirred at room temperature for 24 hours. TLC analysis of the reaction mixture indicated partial consumption of starting material. Ethyl 2-hydroxyacetate (1 mL, 10.57 mmol) and potassium carbonate (2 g, 14.5 mmol) were added and the reaction was stirred at room temperature for 72 hours. TLC analysis of the reaction mixture indicated nearly complete consumption of starting material. The reaction mixture was partially concentrated under reduced pressure for removal of THF. The resulting red solution was diluted with H2O (200 mL) and 1N HCl was added to adjust the pH to 7. The aqueous layer was extracted with EtOAc (3×200 mL). The combined organics were dried over anhydrous Na2SO4 and concentrated in vacuo. The resulting solid was purified by flash column chromatography using a gradient elution of hexanes with 10-70% EtOAc to provide methyl 6-(2-ethoxy-2-oxoethoxy)-5-nitronicotinate (2.43 g, 8.55 mmol, 61.7% yield) as a white solid.

1. customconsumption of starting material
2. stirringthe reaction was stirred at room temperature for 72 hours
3. customconsumption of starting material
4. concentrationThe reaction mixture was partially concentrated under reduced pressure for removal of THF
5. additionThe resulting red solution was diluted with H2O (200 mL) and 1N HCl
6. additionwas added
7. extractionThe aqueous layer was extracted with EtOAc (3×200 mL)
8. dry with materialThe combined organics were dried over anhydrous Na2SO4
9. concentrationconcentrated in vacuo
10. customThe resulting solid was purified by flash column chromatography
11. washa gradient elution of hexanes with 10-70% EtOAc