反应详情

温度

90 °C

To a solution of 5-bromo-2,4-dichloropyrimidine (300 mg, 1.32 mmol) and 2-amino-benzenesulfonamide (340 mg, 1.97 mmol) in 2-propanol (3 mL), concentrated hydrochloric acid (0.06 mL) is added and the mixture is stirred at 90° C. for 4.5 hours. The mixture is poured into aqueous sodium hydrogen carbonate and extracted with ethyl acetate three times. The organic layer is washed with water, dried over sodium sulfate, and evaporated in vacuo. The residue is purified by column chromatography (hexane:ethyl acetate=2:1) to afford the title compound.

1. extractionextracted with ethyl acetate three times
2. washThe organic layer is washed with water
3. dry with materialdried over sodium sulfate
4. customevaporated in vacuo
5. customThe residue is purified by column chromatography (hexane:ethyl acetate=2:1)