2-Pentanol → HCID 21105303, compound

HRID 2426734Notes

Reaction equation

HRID 2426734 reaction equation
[H-].[Na+].[CH3:3][CH:4]([OH:8])[CH2:5][CH2:6][CH3:7].[CH3:9][C:10]([C:12]1[CH:17]=[CH:16][C:15](F)=[C:14]([F:19])[CH:13]=1)=[O:11]>CN(C=O)C.C(OCC)(=O)C>[F:19][C:14]1[CH:13]=[C:12]([C:10](=[O:11])[CH3:9])[CH:17]=[CH:16][C:15]=1[O:8][CH:4]([CH3:3])[CH2:5][CH2:6][CH3:7]

Participants

6

Reactant 3

HCID 223862-PentanolHCID 24758Sodium hydrideHCID 1230521-(3,4-Difluorophenyl)ethan-1-one

Product 1

HCID 21105303HCID 21105303, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 8857Ethyl AcetateSolvent

Procedure

0.058 g of NaH was added to a solution of 0.176 g of 2-pentanol in 2 ml of DMF, and the solution was stirred at room temperature for 1 hour. Then 0.312 g of 3,4-difluoroacetophenone was added, and the mixture was stirred at room temperature overnight. The reaction solution was taken up in ethyl acetate and washed twice with water. The organic phase was dried over sodium sulfate and concentrated in vacuo. The resulting compound was reacted further without further purification.

Workup

  1. stirringthe mixture was stirred at room temperature overnight
  2. washwashed twice with water
  3. dry with materialThe organic phase was dried over sodium sulfate
  4. concentrationconcentrated in vacuo
  5. customThe resulting compound was reacted further without further purification

Sources & evidence

ORD record
ord-5cc6e83dccf44dd298834d7401c46f08
Source dataset
uspto-grants-2011_06
Patent number
US07968550B2

Reaction notes

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