4-Fluorobenzyl chloride → HCID 178505777, compound

HRID 247402Notes

Reaction equation

HRID 247402 reaction equation
[NH:1]1[CH:5]=[C:4]([CH:6]2[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]2)[N:3]=[CH:2]1.C(=O)([O-])[O-].[K+].[K+].[F:18][C:19]1[CH:26]=[CH:25][C:22]([CH2:23]Cl)=[CH:21][CH:20]=1>CN(C)C=O>[F:18][C:19]1[CH:26]=[CH:25][C:22]([CH2:23][N:9]2[CH2:10][CH2:11][CH:6]([C:4]3[N:3]=[CH:2][NH:1][CH:5]=3)[CH2:7][CH2:8]2)=[CH:21][CH:20]=1

Participants

5

Reactant 3

HCID 96024-Fluorobenzyl chlorideHCID 11430Potassium CarbonateHCID 1784208734-(1H-imidazol-4-yl)piperidine

Product 1

HCID 178505777HCID 178505777, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
80 °C

Procedure

To a solution of 1.5 g of 4-(4-imidazolyl)piperidine in 75 cm3 of dimethyl formamide, 2 g of potassium carbonate and 1.5 g of p-fluorobenzyl chloride are added. The mixture is then heated to 80° C. with stirring for 2 hours. The mixture is filtered and the filtrate evaporated under reduced pressure. The residue is recrystallized in acetonitrile. White crystals, M.p. 232° C.

Workup

  1. filtrationThe mixture is filtered
  2. customthe filtrate evaporated under reduced pressure
  3. customThe residue is recrystallized in acetonitrile

Sources & evidence

ORD record
ord-2982e3d670d94f2d96825823237791d6
Source dataset
uspto-grants-1987_11
Patent number
US04707487

Reaction notes

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