Dimethylamine, hydrochloride → HCID 178484439, compound

HRID 24752Notes

Reaction equation

HRID 24752 reaction equation
[C:1]([C:4]1[CH:5]=[C:6]([NH:10]/[C:11](=[C:18]2\[C:19](=[O:27])[NH:20][C:21]3[C:26]\2=[CH:25][CH:24]=[CH:23][CH:22]=3)/[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:7]=[CH:8][CH:9]=1)([OH:3])=O.Cl.[CH3:29][NH:30][CH3:31].CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F.C1C=CC2N(O)N=NC=2C=1>CN(C=O)C.C(N(CC)CC)C>[CH3:29][N:30]([CH3:31])[C:1]([C:4]1[CH:5]=[C:6]([NH:10]/[C:11](=[C:18]2\[C:19](=[O:27])[NH:20][C:21]3[C:26]\2=[CH:25][CH:24]=[CH:23][CH:22]=3)/[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:7]=[CH:8][CH:9]=1)=[O:3]

Participants

7

Reactant 4

HCID 10473Dimethylamine, hydrochlorideHCID 757711-HydroxybenzotriazoleHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 1785170813-[[(Z)-(2-oxo-1H-indol-3-ylidene)-phenylmethyl]amino]benzoic acid

Product 1

HCID 178484439HCID 178484439, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 8471TriethylamineSolvent

Procedure

Prepared analogously to Example 21 from (Z)-3-[1-(3-carboxyphenylamino)-1-phenyl-methylidene]-2-indolinone, dimethylamine-hydrochloride, TBTU, HOBt and triethylamine in DMF.

Sources & evidence

ORD record
ord-7543ce654e57491ba55a3a7794adc116
Source dataset
uspto-grants-2005_02
Patent number
US06855710B2

Reaction notes

Loading…