Water → HCID 57686823, compound

HRID 251814Notes

Reaction equation

HRID 251814 reaction equation
Br[CH2:2][CH2:3][O:4][CH3:5].[OH:6][C:7]1[CH:8]=[C:9]([C:17]([O:19][CH3:20])=[O:18])[CH:10]=[C:11]([CH:16]=1)[C:12]([O:14][CH3:15])=[O:13].C([O-])([O-])=O.[K+].[K+].O>CN(C=O)C>[CH3:5][O:4][CH2:3][CH2:2][O:6][C:7]1[CH:16]=[C:11]([C:12]([O:14][CH3:15])=[O:13])[CH:10]=[C:9]([CH:8]=1)[C:17]([O:19][CH3:20])=[O:18]

Participants

6

Reactant 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 809722-Bromoethyl methyl etherHCID 830651,3-Benzenedicarboxylic acid, 5-hydroxy-, 1,3-dimethyl ester

Product 1

HCID 57686823HCID 57686823, compoundYield 93.7%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

1-bromo-2-methoxyethane(5.8 mmol), dimethyl 5-hydroxyisophthalate(5 mL), K2CO3 (6 mmol) in DMF(10 mL) were stirred for 12 h at 60° C., then the solution was poured into water and the aqueous phase was extracted with EtOAc. The organic phase was washed with brine, dried (MgSO4), filtered, and concentrated to give dimethyl 5-(2-methoxyethoxy)isophthalate (93.7%).

Workup

  1. extractionthe aqueous phase was extracted with EtOAc
  2. washThe organic phase was washed with brine
  3. dry with materialdried (MgSO4)
  4. filtrationfiltered
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-4a397da48e6941c3b4326cd891c223e5
Source dataset
uspto-grants-2011_01
Patent number
US07868001B2

Reaction notes

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