反应详情

Diisopropylethylamine (6.2 mL, 36.0 mmol) and pyrrolidine (2.3 mL, 27.6 mmol) were added to a THF (90 mL) solution of 2-bromo-1-(4-bromophenyl)ethanone (5.0 g, 18.0 mmol), and stirred at room temperature for 2 hours. Saturated sodium bicarbonate water was added to the reaction liquid, extracted with chloroform, and dried with anhydrous magnesium sulfate. The solvent was concentrated under reduced pressure and the obtained residue was purified by silica gel column chromatography (C-200, methanol:chloroform=1:99 to 3:97) to obtain the entitled compound (2.35 g, 49%).

1. extractionextracted with chloroform
2. dry with materialdried with anhydrous magnesium sulfate
3. concentrationThe solvent was concentrated under reduced pressure
4. customthe obtained residue was purified by silica gel column chromatography (C-200, methanol:chloroform=1:99 to 3:97)