Carbon Dioxide → 2-(2-Hydroxyphenyl)-4-thiazoleacetic Acid Ethyl Ester

HRID 260276Notes

Reaction equation

HRID 260276 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[S:10])[NH2:9].Cl[CH2:12][C:13](=O)[CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16].C([O-])(O)=O.[Na+].C(=O)=O>C1COCC1.CCOC(C)=O>[CH2:18]([O:17][C:15](=[O:16])[CH2:14][C:13]1[N:9]=[C:8]([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[OH:1])[S:10][CH:12]=1)[CH3:19]

Participants

7

Reactant 4

HCID 280Carbon DioxideHCID 69484Ethyl 4-chloroacetoacetateHCID 516892Sodium Bicarbonate2×HCID 27593422-Hydroxybenzenecarbothioamide

Product 1

HCID 1360263402-(2-Hydroxyphenyl)-4-thiazoleacetic Acid Ethyl EsterYield 93%

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolventHCID 8857Ethyl AcetateSolvent

Procedure

A stirred solution of 2-hydroxybenzenecarbothioamide 3a (5.36 g, 35.0 mmol), ethyl 4-chloroacetoacetate (6.34 g, 38.5 mmol) in dry THF (70 mL) was heated to reflux under nitrogen for 2.5 days. At ambient temperature, the mixture was diluted with EtOAc (200 mL), then cautiously treated with saturated aq. NaHCO3 (40 mL), and followed by adding solid NaHCO3 in small portions until CO2 evolution ceased. The organic layer was separated, washed with brine (40 mL×2), dried over MgSO4, and filtered. After concentration in vacuo, the oily residue was chromatographed on silica gel (gradient EtOAc/CH2Cl2 : 0-4%) to provide 4a (8.53 g, 93%) as a white solid, which was recrystallized from toluene/hexane at -30° C. mp 35.5°-36.5° C.; IR (neat) 3120, 1740, 1480, 1225 cm-1 ; 1H NMR (DMSO-d6) δ 1.15 (3H, t, J=7.1 Hz, CH3), 3.84 (2H, s, CH2), 4.07 (2H, q, J=7.1 Hz, CH2), 6.89 (1H, t, J=7.8 Hz, Ar), 6.97 (1H, d, J=7.8 Hz, Ar), 7.26 (1H, t, J=7.8 Hz, Ar), 7.48 (1H, s), 7.93 (1H, d, J=7.8 Hz, Ar), 11.29 (1H, s, OH); FABMS m/z 263 (M+), 264 (M++1); Anal. Calcd for C13H13NO3S: C, 59.30; H, 4.98; N, 5.32. Found: C, 59.16; H, 4.97; N, 5.50.

Workup

  1. temperatureto reflux under nitrogen for 2.5 days
  2. customThe organic layer was separated
  3. washwashed with brine (40 mL×2)
  4. dry with materialdried over MgSO4
  5. filtrationfiltered
  6. concentrationAfter concentration in vacuo
  7. customthe oily residue was chromatographed on silica gel (gradient EtOAc/CH2Cl2 : 0-4%)

Sources & evidence

ORD record
ord-892ba8733290415f96df6af5a937b929
Source dataset
uspto-grants-1996_06
Patent number
US05527792

Reaction notes

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