反应详情

By following the procedure of Preparation A1 above, cyclopropyl methyl ketone can be caused to react with 3,4-dichlorobenzaldehyde, 2,4-dichlorobenzaldehyde, 4-bromobenzaldehyde, 4-fluorobenzaldehyde, 4-hydroxybenzaldehyde, 4-trifluoromethoxybenzaldehyde or 4-trifluoromethylbenzaldehyde to give, respectively, 2-(3,4-dichlorophenyl)vinyl cyclopropyl ketone [III; Ar is 3,4--Cl2C6H3, R is H], 2-(2,4-dichlorophenyl)vinyl cyclopropyl ketone [III; Ar is 2,4--Cl2C6H3, R is H], 2-(4-bromophenyl)vinyl cyclopropyl ketone [III; Ar is 4--BrC6H4, R is H], 2-(4-fluorophenyl)vinyl cyclopropyl ketone [III; Ar is 4--FC6H4, R is H], 2-(4-hydroxyphenyl)vinyl cyclopropyl ketone [III; Ar is 4--HOC6H4, R is H], 2-(4-trifluoromethoxyphenyl)vinyl cyclopropyl ketone [III; Ar is 4--F3COC6H4, R is H], or 2-(4-trifluoromethylphenyl)vinyl cyclopropyl ketone [III; Ar is 4--F3CC6H4, R is H]. 2-(4-Hydroxyphenyl)vinyl cyclopropyl ketone can be esterified with benzoyl chloride to give 2-(4-benzoyloxyphenyl)vinyl cyclopropyl ketone [III; Ar is 4--C6H5COOC6H4, R is H].

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