Hydrochloric Acid → HCID 86619419, compound

HRID 269605Notes

Reaction equation

HRID 269605 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]2[C:13]3[CH:14]=[CH:15][C:16]([O:75][CH2:76][C:77]4[CH:82]=[CH:81][CH:80]=[CH:79][CH:78]=4)=[C:17]([CH:74]=3)[CH2:18][C@H:19]([NH:63][C:64]([O:66][CH2:67][C:68]3[CH:73]=[CH:72][CH:71]=[CH:70][CH:69]=3)=[O:65])[C:20](=[O:62])[NH:21][C@@H:22]([CH2:40][C@@H:41]([O:54][Si:55]([C:58]([CH3:61])([CH3:60])[CH3:59])([CH3:57])[CH3:56])[CH2:42][NH:43][C:44]([O:46][CH2:47][C:48]3[CH:53]=[CH:52][CH:51]=[CH:50][CH:49]=3)=[O:45])[C:23](=[O:39])[NH:24][C@H:25]([C:29]([O:31]CC3C=CC=CC=3)=[O:30])[CH2:26][C:27]=1[CH:28]=2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.CO.[OH-].[Li+].Cl>C1COCC1.O>[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]2[C:13]3[CH:14]=[CH:15][C:16]([O:75][CH2:76][C:77]4[CH:78]=[CH:79][CH:80]=[CH:81][CH:82]=4)=[C:17]([CH:74]=3)[CH2:18][C@H:19]([NH:63][C:64]([O:66][CH2:67][C:68]3[CH:73]=[CH:72][CH:71]=[CH:70][CH:69]=3)=[O:65])[C:20](=[O:62])[NH:21][C@@H:22]([CH2:40][C@@H:41]([O:54][Si:55]([C:58]([CH3:61])([CH3:60])[CH3:59])([CH3:57])[CH3:56])[CH2:42][NH:43][C:44]([O:46][CH2:47][C:48]3[CH:53]=[CH:52][CH:51]=[CH:50][CH:49]=3)=[O:45])[C:23](=[O:39])[NH:24][C@H:25]([C:29]([OH:31])=[O:30])[CH2:26][C:27]=1[CH:28]=2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 3939Lithium HydroxideHCID 86619420HCID 86619420, compound

Product 1

HCID 86619419HCID 86619419, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolvent2×HCID 8028TetrahydrofuranSolvent

Procedure

210 mg (0.19 mmol) of the compound from Example 66A are dissolved in 2 ml of THF, and 1 ml each of water and methanol are added. After the addition of 13 mg (0.56 mmol) of lithium hydroxide the mixture is stirred at RT for 12 h. The reaction solution is then diluted with 30 ml of water and adjusted to pH=3 by adding 1N hydrochloric acid. The precipitate is collected by filtration and dried under high vacuum.

Workup

  1. filtrationThe precipitate is collected by filtration
  2. customdried under high vacuum

Sources & evidence

ORD record
ord-0c8a550ef7684aebb2ac71a683bf3f38
Source dataset
uspto-grants-2008_11
Patent number
US07446102B2

Reaction notes

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