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HRID269808

反应详情

EQUATION

反应方程式

HRID 269808 的结构方程式

REACTANTS

反应物

4
结构：CN(C)CC(=O)O.Cl
HCID75605

Glycine, N,N-dimethyl-, hydrochloride

C4H10ClNO2

结构：On1nnc2ccccc21
HCID75771

1-Hydroxybenzotriazole

C6H5N3O

结构：O=[N+]([O-])c1ccc(N2CCNCC2)cc1
HCID80447

1-(4-Nitrophenyl)piperazine

C10H13N3O2

结构：CCN=C=NCCCN(C)C.Cl
HCID2723939

1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride

C8H18ClN3

PRODUCTS

生成物

1
结构：CN(C)CC(=O)N1CCN(c2ccc(N)cc2)CC1
HCID23071545

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CCN(CC)CC
溶剂HCID8471

Triethylamine

C6H15N

结构：CN1CCCC1=O
溶剂HCID13387

N-Methyl-2-pyrrolidone

C5H9NO

PROCEDURE

实验过程

1-(4-nitrophenyl)piperazine and N,N-dimethylglycine hydrochloride were allowed to undergo the reaction using WSC hydrochloride and HOBt in 1-methyl-2-pyrrolidone in the presence of triethylamine. The resulting compound was subjected to-catalytic hydrogenation in the same manner as shown in Reference Example 3 to obtain 1-[4-(4-aminophenyl)piperazin-1-yl]-2-dimethylaminoethanone. NMR2: 2.30 (6H, s), 3.74-3.76 (4H, m), 6.64-6.68 (2H, m).