反应详情

A mixture of Example 516A, 1-vinyl-2-pyrrolidinone, Pd(dppf)Cl2-CH2Cl2, and triethylamine in DMF was heated at 110° C. overnight, cooled to room temperature, diluted with ethyl acetate, washed with water and brine, dried (MgSO4), filtered and concentrated. The concentrate was purified by column chromatography on silica gel using a solvent gradient that increased from 1 to 4% methanol in dichloromethane to give the title compound. MS (ESI) m/e 384 (M+H)+.

1. washwashed with water and brine
2. dry with materialdried (MgSO4)
3. filtrationfiltered
4. concentrationconcentrated
5. customThe concentrate was purified by column chromatography on silica gel using a solvent gradient that
6. temperatureincreased from 1 to 4% methanol in dichloromethane