2-Bromopropane → HCID 13826357, compound

HRID 277914Notes

Reaction equation

HRID 277914 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:9][C:10]#[N:11])[CH:6]=[CH:7][CH:8]=1.[H-].[Na+].Br[CH:15]([CH3:17])[CH3:16]>CN(C=O)C>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:9]([CH:15]([CH3:17])[CH3:16])[C:10]#[N:11])[CH:6]=[CH:7][CH:8]=1

Participants

5

Reactant 3

HCID 63582-BromopropaneHCID 24758Sodium hydrideHCID 88310(3-Methoxyphenyl)acetonitrile

Product 1

HCID 13826357HCID 13826357, compoundYield 79.9%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

By working in a way similar to that described in example 16 but using 3-methoxy-phenyl-acetonitrile (4.4 g, 30 mmoles), anhydrous DMF (40 ml), NaH (55-65%, 1.44 g, 36.3 mmoles) and 2-bromo-propane (4.46 g, 36.3 mmoles), 4.53 g of the title compound were obtained (yield: 79.9%).

Sources & evidence

ORD record
ord-652326dd20424f0c89c4746a3d50d6b9
Source dataset
uspto-grants-2002_03
Patent number
US06358973B1

Reaction notes

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