Triethylamine → HCID 11316133, compound

HRID 277918Notes

Reaction equation

HRID 277918 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:12])[C:7]=1[CH2:8][C:9]([OH:11])=O.C(N1C=CN=C1)(N1C=CN=C1)=O.[CH:25]1([CH2:30][C:31]2[C:36]([O:37][CH3:38])=[CH:35][CH:34]=[CH:33][C:32]=2[CH2:39][CH2:40][NH2:41])[CH2:29][CH2:28][CH2:27][CH2:26]1.C(N(CC)CC)C>C1COCC1>[CH:25]1([CH2:30][C:31]2[C:36]([O:37][CH3:38])=[CH:35][CH:34]=[CH:33][C:32]=2[CH2:39][CH2:40][NH:41][C:9](=[O:11])[CH2:8][C:7]2[C:6]([Cl:12])=[CH:5][N:4]=[CH:3][C:2]=2[Cl:1])[CH2:26][CH2:27][CH2:28][CH2:29]1

Participants

6

Reactant 4

HCID 8471TriethylamineHCID 682631,1'-CarbonyldiimidazoleHCID 22626827HCID 22626827, compoundHCID 22626829HCID 22626829, compound

Product 1

HCID 11316133HCID 11316133, compoundYield 86%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

By working in a way similar to that described in example 4 but using (3,5-dichloro-pyridin-4-yl)-acetic acid (356 mg, 1.73 mmoles), carbonyldiimidazole (308 mg, 1.9 mmoles), THF (15 ml), 2-(2-cyclopentylmethyl-3-methoxy-phenyl)-ethylamine (390 mg, 1.44 mmoles), obtained as described in example 49, and triethylamine (0.24 ml, 1.73 mmoles), 520 mg of the title compound were obtained (yield: 86%).

Workup

  1. customobtained

Sources & evidence

ORD record
ord-aaf2ee7811ad4f84ae6d102533b0923e
Source dataset
uspto-grants-2002_03
Patent number
US06358973B1

Reaction notes

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