Methyl iodide → HCID 18936306, compound

HRID 2825Notes

Reaction equation

HRID 2825 reaction equation
[O:1]1[CH:5]=[CH:4][C:3]([C:6]([C:9]2[O:13][C:12]([CH3:14])=[N:11][C:10]=2[CH3:15])([OH:8])[CH3:7])=[CH:2]1.[H-].[Na+].CI.[C:20](=O)([O-])O.[Na+]>CN(C)C=O>[CH3:20][O:8][C:6]([C:9]1[O:13][C:12]([CH3:14])=[N:11][C:10]=1[CH3:15])([C:3]1[CH:4]=[CH:5][O:1][CH:2]=1)[CH3:7]

Participants

6

Reactant 4

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 516892Sodium BicarbonateHCID 18936311HCID 18936311, compound

Product 1

HCID 18936306HCID 18936306, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent2×

Procedure

1-(3-Furyl)-1-(2,4-dimethyl-5-oxazolyl)ethanol (2g) in dry N,N-dimethylformamide (15 ml) was added to a stirred suspension of sodium hydride (80%, 300 mg) in dry N,N-dimethylformamide (10 ml) at 0° C. After 20 minutes, methyl iodide (1.5 g) was added dropwise. The mixture was allowed to warm to room temperature and after 30 minutes aqueous sodium hydrogen carbonate was added.

Workup

  1. additionwas added

Sources & evidence

ORD record
ord-59fd6eb77b07405893186404a2c88e70
Source dataset
uspto-grants-1998_03
Patent number
US05731335

Reaction notes

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