Hydrochloric Acid → 2-[3-bromo-4-[(2,4-difluorobenzyl)oxy]-6-methyl-2-oxopyridin-1(2H)-yl]-N,N'-dimethylterephthalamide

HRID 289903Notes

Reaction equation

HRID 289903 reaction equation
[Br:1][c:2]1[c:3](=[O:32])[n:4](-[c:19]2[c:20]([C:21](=[O:22])[OH:23])[cH:24][cH:25][c:26]([C:28](=[O:29])[NH:30][CH3:31])[cH:27]2)[c:5]([CH3:18])[cH:6][c:7]1[O:8][CH2:9][c:10]1[c:11]([F:17])[cH:12][c:13]([F:16])[cH:14][cH:15]1.[C:69](#[N:70])[CH3:71].[CH3:34][N:35]([CH3:36])[CH2:37][CH2:38][CH2:39][CH:40]([N:41]=[C:42]=[NH:43])[CH3:44].[CH3:55][NH2:56].[CH3:62][CH2:63][O:64][C:65](=[O:66])[CH3:67].[ClH:33].[O:57]=[CH:58][N:59]([CH3:60])[CH3:61].[OH2:68].[OH:45][n:46]1[c:47]2[cH:48][cH:49][cH:50][cH:51][c:52]2[n:53][n:54]1>>[Br:1][c:2]1[c:3](=[O:32])[n:4](-[c:19]2[c:20]([C:21](=[O:23])[NH:35][CH3:34])[cH:24][cH:25][c:26]([C:28](=[O:29])[NH:30][CH3:31])[cH:27]2)[c:5]([CH3:18])[cH:6][c:7]1[O:8][CH2:9][c:10]1[c:11]([F:17])[cH:12][c:13]([F:16])[cH:14][cH:15]1

Participants

10

Reactant 9

HCID 313Hydrochloric AcidHCID 962WaterHCID 6228DimethylformamideHCID 6329MethylamineHCID 6342AcetonitrileHCID 8857Ethyl AcetateHCID 757711-HydroxybenzotriazoleHCID 193623961-(3-Dimethylaminopropyl)-ethylcarbodiimideHCID 220508892-[3-bromo-4-[(2,4-difluorobenzyl)oxy]-6-methyl-2-oxopyridin-1(2H)-yl]-4-[(methylamino)carbonyl] benzoic Acid

Product 1

HCID 220503552-[3-bromo-4-[(2,4-difluorobenzyl)oxy]-6-methyl-2-oxopyridin-1(2H)-yl]-N,N'-dimethylterephthalamide

Sources & evidence

ORD record
ord-259b3f50a8c348798f7001a9029d5f59
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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