Hydrochloric Acid → N-cyclobutyl-4-[3-(1-quinolin-6-ylcyclopropyl)imidazo[1,2-a]pyrimidin-6-yl]benzamide

HRID 290002Notes

Reaction equation

HRID 290002 reaction equation
[CH3:75][N:76]([CH3:77])[CH:78]=[O:79].[CH3:80][OH:81].[CH:1]([N:2]([CH2:3][CH3:4])[CH:5]([CH3:6])[CH3:7])([CH3:8])[CH3:9].[CH:43]1([NH2:47])[CH2:44][CH2:45][CH2:46]1.[ClH:10].[ClH:11].[P-:48]([F:49])([F:50])([F:51])([F:52])([F:53])[F:54].[n:12]1[cH:13][cH:14][cH:15][c:16]2[cH:17][c:18]([C:22]3([c:25]4[cH:26][n:27][c:28]5[n:29]4[cH:30][c:31](-[c:34]4[cH:35][cH:36][c:37]([C:38](=[O:39])[OH:40])[cH:41][cH:42]4)[cH:32][n:33]5)[CH2:23][CH2:24]3)[cH:19][cH:20][c:21]12.[n:55]1([O:56][P+:57]([N:58]([CH3:59])[CH3:60])([N:61]([CH3:62])[CH3:63])[N:64]([CH3:65])[CH3:66])[c:67]2[cH:68][cH:69][cH:70][cH:71][c:72]2[n:73][n:74]1>>[n:12]1[cH:13][cH:14][cH:15][c:16]2[cH:17][c:18]([C:22]3([c:25]4[cH:26][n:27][c:28]5[n:29]4[cH:30][c:31](-[c:34]4[cH:35][cH:36][c:37]([C:38](=[O:39])[NH:47][CH:43]6[CH2:44][CH2:45][CH2:46]6)[cH:41][cH:42]4)[cH:32][n:33]5)[CH2:23][CH2:24]3)[cH:19][cH:20][c:21]12

Participants

9

Reactant 8

HCID 313Hydrochloric Acid2×HCID 887MethanolHCID 6228DimethylformamideHCID 9886HexafluorophosphateHCID 75645CyclobutylamineHCID 81531DiisopropylethylamineHCID 124335Benzotriazol-1-yloxy-tris(dimethylamino)phosphoniumHCID 672233304-[3-(1-Quinolin-6-ylcyclopropyl)imidazo[1,2-a]pyrimidin-6-yl]benzoic acid

Product 1

HCID 25143838N-cyclobutyl-4-[3-(1-quinolin-6-ylcyclopropyl)imidazo[1,2-a]pyrimidin-6-yl]benzamide

Sources & evidence

ORD record
ord-9a68f260d1074462858872d46ebee125
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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