反应详情

To a solution of phenylacetaldehyde (6.0 g, 50 mmol) and 2-phenylethylamine in THF (200 mL) is added sodium triacetoxy-borohydride drop wise. The solution is stirred under nitrogen overnight at room temperature. The solution is quenched with aq. saturated sodium bicarbonate (200 mL), and extracted with EtOAc (4×100 mL). The organic extracts are combined, dried and concentrated under vacuum. The residue is purified by flash chromatography (silica gel; EtOAc/MeOH 9:1) to provide 1.25 g (11%) of the compound D as a clear oil. M+H+=226.10.

1. customThe solution is quenched with aq. saturated sodium bicarbonate (200 mL)
2. extractionextracted with EtOAc (4×100 mL)
3. customdried
4. concentrationconcentrated under vacuum
5. customThe residue is purified by flash chromatography (silica gel; EtOAc/MeOH 9:1)