Dimethylformamide → 4-(4-Ethynyl-2-fluoro-phenylamino)-1-methyl-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid ethyl ester

HRID 292320Notes

Reaction equation

HRID 292320 reaction equation
[C:23](#[CH:24])[Si:25]([CH3:26])([CH3:27])[CH3:28].[CH2:1]([CH3:2])[O:3][C:4](=[O:5])[c:6]1[cH:7][n:8]([CH3:22])[c:9](=[O:21])[cH:10][c:11]1[NH:12][c:13]1[c:14]([F:20])[cH:15][c:16]([I:19])[cH:17][cH:18]1.[CH2:47]1[O:48][CH2:49][CH2:50][CH2:51]1.[CH3:30][CH2:31][CH2:32][CH2:33][N+:34]([CH2:35][CH2:36][CH2:37][CH3:38])([CH2:39][CH2:40][CH2:41][CH3:42])[CH2:43][CH2:44][CH2:45][CH3:46].[Cu:57][I:58].[F-:29].[O:52]=[CH:53][N:54]([CH3:55])[CH3:56]>>[CH2:1]([CH3:2])[O:3][C:4](=[O:5])[c:6]1[cH:7][n:8]([CH3:22])[c:9](=[O:21])[cH:10][c:11]1[NH:12][c:13]1[c:14]([F:20])[cH:15][c:16]([C:23]#[CH:24])[cH:17][cH:18]1

Participants

8

Reactant 7

HCID 6228DimethylformamideHCID 8028TetrahydrofuranHCID 16028TetrabutylammoniumHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 28179Fluoride IonHCID 66111TrimethylsilylacetyleneHCID 11362025Ethyl 4-(2-fluoro-4-iodoanilino)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxylate

Product 1

HCID 117714024-(4-Ethynyl-2-fluoro-phenylamino)-1-methyl-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid ethyl ester

Sources & evidence

ORD record
ord-7a114106144f4d708830b9c118562aed
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

Loading…