Hydrochloric Acid → 6-[2-[2-(cyclopropylmethoxy)-3-methoxyphenyl]ethenyl]-N-[4-(trifluoromethoxy)phenyl]imidazo[2,1-b][1,3]thiazole-5-carboxamide

HRID 292910Notes

Reaction equation

HRID 292910 reaction equation
[CH3:39][CH2:40][N:41]=[C:42]=[N:43][CH2:44][CH2:45][CH2:46][N:47]([CH3:48])[CH3:49].[CH3:51][N:52]([c:53]1[cH:54][cH:55][n:56][cH:57][cH:58]1)[CH3:59].[CH:1]1([CH2:4][O:5][c:6]2[c:7]([CH:14]=[CH:15][c:16]3[n:17][c:18]4[s:19][cH:20][cH:21][n:22]4[c:23]3[C:24](=[O:25])[OH:26])[cH:8][cH:9][cH:10][c:11]2[O:12][CH3:13])[CH2:2][CH2:3]1.[Cl:60][CH2:61][Cl:62].[ClH:50].[F:27][C:28]([O:29][c:30]1[cH:31][cH:32][c:33]([NH2:34])[cH:35][cH:36]1)([F:37])[F:38].[O:63]=[CH:64][N:65]([CH3:66])[CH3:67]>>[CH:1]1([CH2:4][O:5][c:6]2[c:7]([CH:14]=[CH:15][c:16]3[n:17][c:18]4[s:19][cH:20][cH:21][n:22]4[c:23]3[C:24](=[O:26])[NH:34][c:33]3[cH:32][cH:31][c:30]([O:29][C:28]([F:27])([F:37])[F:38])[cH:36][cH:35]3)[cH:8][cH:9][cH:10][c:11]2[O:12][CH3:13])[CH2:2][CH2:3]1

Participants

8

Reactant 7

HCID 313Hydrochloric AcidHCID 6228DimethylformamideHCID 6344DichloromethaneHCID 142844-(Dimethylamino)pyridineHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 6008484-(Trifluoromethoxy)anilineHCID 684059436-[2-[2-(Cyclopropylmethoxy)-3-methoxyphenyl]ethenyl]imidazo[2,1-b][1,3]thiazole-5-carboxylic acid

Product 1

HCID 675498256-[2-[2-(cyclopropylmethoxy)-3-methoxyphenyl]ethenyl]-N-[4-(trifluoromethoxy)phenyl]imidazo[2,1-b][1,3]thiazole-5-carboxamide

Sources & evidence

ORD record
ord-dc13291625c447dc830b3b7e0535c796
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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