Hydrochloric Acid → Trifluoroacetic acid

HRID 298164Notes

Reaction equation

HRID 298164 reaction equation
[CH3:33][N:34]1[CH2:35][CH2:36][O:37][CH2:38][CH2:39]1.[ClH:17].[ClH:18].[F:1][CH:2]([O:3][c:4]1[cH:5][cH:6][c:7]([C:10]2([C:13](=[O:14])[OH:15])[CH2:11][CH2:12]2)[cH:8][cH:9]1)[F:16].[F:40][C:41]([C:42](=[O:43])[OH:44])([F:45])[F:46].[NH:19]1[CH2:20][C:21]2([O:22][C:23](=[O:30])[c:24]3[cH:25][n:26][cH:27][cH:28][c:29]32)[CH2:31][CH2:32]1.[O:47]=[CH:48][N:49]([CH3:50])[CH3:51]>>[F:1][CH:2]([O:3][c:4]1[cH:5][cH:6][c:7]([C:10]2([C:13](=[O:15])[N:19]3[CH2:20][C:21]4([O:22][C:23](=[O:30])[c:24]5[cH:25][n:26][cH:27][cH:28][c:29]54)[CH2:31][CH2:32]3)[CH2:11][CH2:12]2)[cH:8][cH:9]1)[F:16].[F:40][C:41]([C:42](=[O:43])[OH:44])([F:45])[F:46]

Participants

8

Reactant 6

HCID 313Hydrochloric Acid2×HCID 6228DimethylformamideHCID 6422Trifluoroacetic acidHCID 79724-MethylmorpholineHCID 289377331-[4-(Difluoromethoxy)phenyl]cyclopropanecarboxylic acidHCID 666621763H-spiro[furo[3,4-c]pyridine-1,3'-pyrrolidin]-3-one

Product 2

HCID 6422Trifluoroacetic acidHCID 666617191'-[1-[4-(Difluoromethoxy)phenyl]cyclopropanecarbonyl]spiro[furo[3,4-c]pyridine-1,3'-pyrrolidine]-3-one

Sources & evidence

ORD record
ord-6aa1fe538859492797d44aa1b26af32f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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