Hydrochloric Acid → (4-Benzyloxy-phenyl)-(6-(trimethylsilylethynyl)quinazolin-4-yl)-amine

HRID 299337Notes

Reaction equation

HRID 299337 reaction equation
[CH2:2]([c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1)[O:9][c:10]1[cH:11][cH:12][c:13]([NH:16][c:17]2[n:18][cH:19][n:20][c:21]3[cH:22][cH:23][c:24]([I:27])[cH:25][c:26]23)[cH:14][cH:15]1.[CH3:28][Si:29]([CH3:30])([CH3:31])[C:32]#[CH:33].[CH3:34][CH2:35][N:36]([CH2:37][CH3:38])[CH2:39][CH3:40].[CH3:41][C:42]#[N:43].[ClH:1].[Cu:44][I:45]>>[CH2:2]([c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1)[O:9][c:10]1[cH:11][cH:12][c:13]([NH:16][c:17]2[n:18][cH:19][n:20][c:21]3[cH:22][cH:23][c:24]([C:33]#[C:32][Si:29]([CH3:28])([CH3:30])[CH3:31])[cH:25][c:26]23)[cH:14][cH:15]1

Participants

7

Reactant 6

HCID 313Hydrochloric AcidHCID 6342AcetonitrileHCID 8471TriethylamineHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 66111TrimethylsilylacetyleneHCID 21951950(4-Benzyloxy-phenyl)-(6-iodoquinazolin-4-yl)-amine

Product 1

HCID 22609859(4-Benzyloxy-phenyl)-(6-(trimethylsilylethynyl)quinazolin-4-yl)-amine

Sources & evidence

ORD record
ord-01243324bebb40a498b6ca22a1bcae51
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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