Triethylamine → 4-(4-Fluorophenyl)but-3-yn-1-ol

HRID 299998Notes

Reaction equation

HRID 299998 reaction equation
[Br:20][c:21]1[cH:22][cH:23][c:24]([F:27])[cH:25][cH:26]1.[CH2:28]([CH2:29][C:30]#[CH:31])[OH:32].[CH3:33][CH2:34][N:35]([CH2:36][CH3:37])[CH2:38][CH3:39].[Cu:81]([I:82])[I:83].[Pd:40]([Cl:41])[Cl:42].[c:1]1([P:2]([c:3]2[cH:4][cH:5][cH:6][cH:7][cH:8]2)[c:9]2[cH:10][cH:11][cH:12][cH:13][cH:14]2)[cH:15][cH:16][cH:17][cH:18][cH:19]1.[c:43]1([P:44]([c:45]2[cH:46][cH:47][cH:48][cH:49][cH:50]2)[c:51]2[cH:52][cH:53][cH:54][cH:55][cH:56]2)[cH:57][cH:58][cH:59][cH:60][cH:61]1.[c:62]1([P:63]([c:64]2[cH:65][cH:66][cH:67][cH:68][cH:69]2)[c:70]2[cH:71][cH:72][cH:73][cH:74][cH:75]2)[cH:76][cH:77][cH:78][cH:79][cH:80]1>>[c:21]1([C:31]#[C:30][CH2:29][CH2:28][OH:32])[cH:22][cH:23][c:24]([F:27])[cH:25][cH:26]1

Participants

7

Reactant 6

HCID 8471TriethylamineHCID 99931-Bromo-4-fluorobenzeneHCID 11776Triphenylphosphine3×HCID 135663-Butyn-1-OLHCID 24290Palladium ChlorideHCID 83717Copper iodide

Product 1

HCID 124784404-(4-Fluorophenyl)but-3-yn-1-ol

Sources & evidence

ORD record
ord-f8f7f6c0e11a4abc98cd5887f21ee63a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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