Triethylamine → Propyl-[1-(4-trimethylsilanylethynylphenyl)-cyclopropyl]-amine

HRID 307796Notes

Reaction equation

HRID 307796 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]([C:8]2([NH:11][CH2:12][CH2:13][CH3:14])[CH2:9][CH2:10]2)[cH:6][cH:7]1.[CH3:15][Si:16]([CH3:17])([CH3:18])[C:19]#[CH:20].[CH3:21][CH2:22][N:23]([CH2:24][CH3:25])[CH2:26][CH3:27].[Cu:28][I:29].[Pd:30]([Cl:31])[Cl:32].[c:33]1([P:34]([c:35]2[cH:36][cH:37][cH:38][cH:39][cH:40]2)[c:41]2[cH:42][cH:43][cH:44][cH:45][cH:46]2)[cH:47][cH:48][cH:49][cH:50][cH:51]1.[c:52]1([P:53]([c:54]2[cH:55][cH:56][cH:57][cH:58][cH:59]2)[c:60]2[cH:61][cH:62][cH:63][cH:64][cH:65]2)[cH:66][cH:67][cH:68][cH:69][cH:70]1>>[c:2]1([C:20]#[C:19][Si:16]([CH3:15])([CH3:17])[CH3:18])[cH:3][cH:4][c:5]([C:8]2([NH:11][CH2:12][CH2:13][CH3:14])[CH2:9][CH2:10]2)[cH:6][cH:7]1

Participants

7

Reactant 6

HCID 8471TriethylamineHCID 11776Triphenylphosphine2×HCID 24290Palladium ChlorideHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 66111TrimethylsilylacetyleneHCID 22568814[1-(4-Bromophenyl)-cyclopropyl]-propylamine

Product 1

HCID 22568956Propyl-[1-(4-trimethylsilanylethynylphenyl)-cyclopropyl]-amine

Sources & evidence

ORD record
ord-3a6a7fd479004bfaa29aa9fd39a6015c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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