Dimethylformamide → 5-Amino-N-[2-({[(2,6-dibromophenyl)carbonyl]amino}methyl)-3,3,3-trifluoro-2-hydroxypropyl]-1-(4-fluorophenyl)-1H-pyrazole-4-carboxamide
Reaction equation
[Br:1][c:2]1[c:3]([C:4](=[O:5])[OH:6])[c:7]([Br:11])[cH:8][cH:9][cH:10]1.[CH3:57][N:58]([CH3:59])[CH:60]=[O:61].[CH:43]([N:44]([CH:45]([CH3:46])[CH3:47])[CH2:48][CH3:49])([CH3:50])[CH3:51].[Cl:12][C:13]([C:14]([Cl:15])=[O:16])=[O:17].[NH2:18][c:19]1[c:20]([C:31](=[O:32])[NH:33][CH2:34][C:35]([C:36]([F:37])([F:38])[F:39])([OH:40])[CH2:41][NH2:42])[cH:21][n:22][n:23]1-[c:24]1[cH:25][cH:26][c:27]([F:30])[cH:28][cH:29]1.[O:52]1[CH2:53][CH2:54][CH2:55][CH2:56]1>>[Br:1][c:2]1[c:3]([C:4](=[O:6])[NH:42][CH2:41][C:35]([CH2:34][NH:33][C:31]([c:20]2[c:19]([NH2:18])[n:23](-[c:24]3[cH:25][cH:26][c:27]([F:30])[cH:28][cH:29]3)[n:22][cH:21]2)=[O:32])([C:36]([F:37])([F:38])[F:39])[OH:40])[c:7]([Br:11])[cH:8][cH:9][cH:10]1Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-258f437e9a004adab2ad09aee70597bc
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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