1,2-Dichloroethane → (5-{3-[(5-Bromo-pyridine-2-carbonyl)-amino]-phenyl}-5-fluoromethyl-5,6-dihydro-2H-[1,4]oxazin-3-yl)-carbamic acid tert-butyl ester
Reaction equation
[Br:24][c:25]1[cH:26][cH:27][c:28]([C:31](=[O:32])[OH:33])[n:29][cH:30]1.[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([NH:7][C:8]1=[N:13][C:12]([CH2:14][F:15])([c:16]2[cH:17][c:18]([NH2:22])[cH:19][cH:20][cH:21]2)[CH2:11][O:10][CH2:9]1)=[O:23].[CH2:41]([Cl:42])[CH2:43][Cl:44].[CH3:34][CH2:35][N:36]([CH2:37][CH3:38])[CH2:39][CH3:40].[CH3:49][CH2:50][O:51][C:52]([CH3:53])=[O:54].[Cl:46][CH2:47][Cl:48].[ClH:45]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([NH:7][C:8]1=[N:13][C:12]([CH2:14][F:15])([c:16]2[cH:17][c:18]([NH:22][C:31]([c:28]3[cH:27][cH:26][c:25]([Br:24])[cH:30][n:29]3)=[O:32])[cH:19][cH:20][cH:21]2)[CH2:11][O:10][CH2:9]1)=[O:23]Participants
8
Reactant 7
Product 1
Sources & evidence
- ORD record
- ord-98895f3b2c71494dba873a68b39f280d
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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