Dimethylformamide → 5-((trimethylsilyl)ethynyl)pyrimidine-2,4(1H,3H)-dione

HRID 316201Notes

Reaction equation

HRID 316201 reaction equation
[CH3:10][Si:11]([CH3:12])([CH3:13])[C:14]#[CH:15].[CH3:16][CH2:17][N:18]([CH2:19][CH3:20])[CH2:21][CH3:22].[Cu:28][I:29].[I:1][c:2]1[c:3](=[O:9])[nH:4][c:5](=[O:8])[nH:6][cH:7]1.[O:23]=[CH:24][N:25]([CH3:26])[CH3:27]>>[c:2]1([C:15]#[C:14][Si:11]([CH3:10])([CH3:12])[CH3:13])[c:3](=[O:9])[nH:4][c:5](=[O:8])[nH:6][cH:7]1

Participants

6

Reactant 5

HCID 6228DimethylformamideHCID 8471TriethylamineHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 66111TrimethylsilylacetyleneHCID 696725-Iodouracil

Product 1

HCID 127820375-((trimethylsilyl)ethynyl)pyrimidine-2,4(1H,3H)-dione

Sources & evidence

ORD record
ord-30e15ee9afad48bb80375435792f4050
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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