Hydrochloric Acid → 6-Pyrazol-1-yl-imidazo[1,2-a]pyridine-2-carboxylic acid {2-[4-(2-chloro-phenoxy)-piperidin-1-yl]-2-oxo-ethyl}-amide

HRID 317335Notes

Reaction equation

HRID 317335 reaction equation
[CH3:20][CH2:21][N:22]=[C:23]=[N:24][CH2:25][CH2:26][CH2:27][N:28]([CH3:29])[CH3:30].[CH:1]([N:2]([CH2:3][CH3:4])[CH:5]([CH3:6])[CH3:7])([CH3:8])[CH3:9].[ClH:48].[NH2:49][CH2:50][C:51](=[O:52])[N:53]1[CH2:54][CH2:55][CH:56]([O:59][c:60]2[c:61]([Cl:66])[cH:62][cH:63][cH:64][cH:65]2)[CH2:57][CH2:58]1.[O:67]=[CH:68][N:69]([CH3:70])[CH3:71].[OH2:72].[OH:10][n:11]1[c:12]2[c:13]([cH:14][cH:15][cH:16][cH:17]2)[n:18][n:19]1.[n:31]1(-[c:36]2[cH:37][cH:38][c:39]3[n:40]([cH:41]2)[cH:42][c:43]([C:45](=[O:46])[OH:47])[n:44]3)[n:32][cH:33][cH:34][cH:35]1>>[n:31]1(-[c:36]2[cH:37][cH:38][c:39]3[n:40]([cH:41]2)[cH:42][c:43]([C:45](=[O:47])[NH:49][CH2:50][C:51](=[O:52])[N:53]2[CH2:54][CH2:55][CH:56]([O:59][c:60]4[c:61]([Cl:66])[cH:62][cH:63][cH:64][cH:65]4)[CH2:57][CH2:58]2)[n:44]3)[n:32][cH:33][cH:34][cH:35]1

Participants

9

Reactant 8

HCID 313Hydrochloric AcidHCID 962WaterHCID 6228DimethylformamideHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 757711-HydroxybenzotriazoleHCID 81531DiisopropylethylamineHCID 578744966-Pyrazol-1-yl-imidazo[1,2-a]pyridine-2-carboxylic acidHCID 593762772-Amino-1-[4-(2-chlorophenoxy)piperidin-1-yl]ethanone

Product 1

HCID 578745136-Pyrazol-1-yl-imidazo[1,2-a]pyridine-2-carboxylic acid {2-[4-(2-chloro-phenoxy)-piperidin-1-yl]-2-oxo-ethyl}-amide

Sources & evidence

ORD record
ord-34f59c1e3cb344e5992cde9776279fca
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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