反应详情

A suspension of 1-bromo-3-phenoxybenzene (2.01 g; 8.08 mmol), PdCl2(PPh3)2 (296 mg; 0.42 mmol), allyl tributyltin 3.13 g; 9.46 mmol), triphenylphosphine (455 mg; 1.73 mmol) and LiCl (1.39 g; 33 mmol) in 10 ml DMF was stirred at 100° C. for 3 h. After cooling to r.t the mixture was diluted with Et2O (75 ml), washed with water (3×50 ml) and brine, dried over MgSO4 and concentrated. Flash chromatography with hexane afforded the desired material.

1. temperatureAfter cooling
2. washwashed with water (3×50 ml) and brine
3. dry with materialdried over MgSO4
4. concentrationconcentrated