反应详情

To a solution of 2-methylaniline (1.0 g) and triethylamine (0.95 g) in N,N-dimethylformamide (15 ml) was added benzyl bromide (1.9 g) at ambient temperature and the mixture was stirred at ambient temperature overnight. The reaction mixture was diluted with ethyl acetate and it was washed with water and brine. Drying, filtering and the removal of solvents afforded a crude product. The crude product was chromatographed on silica gel (n-hexane:ethyl acetate=10:1) to give N-benzyl-2-methylaniline (795 mg) as a slightly yellow oil.

1. washwas washed with water and brine
2. customDrying
3. filtrationfiltering
4. customthe removal of solvents
5. customafforded a crude product
6. customThe crude product was chromatographed on silica gel (n-hexane:ethyl acetate=10:1)