反应详情

A solution of 3-bromopyridine (7.9 g), methyl 4-pentenoate (7.15 g), palladium acetate (0.11 g) and tri-o-tolylphosphine (0.6 g) in 50 ml of triethylamine is refluxed for 24 hours under argon and the solvent evaporated. The residue is taken up in methylene chloride (50 ml) and washed with water (2×40 ml). The organic phase is dried and evaporated to yield 3-(4-methoxycarbonylbut-1-enyl)pyridine as a colorless liquid; NMR (CDCl3) 3.72 (s, 3 H), 6.40 (s, 1 H); IR (film) 1725 cm-1.

1. customthe solvent evaporated
2. washwashed with water (2×40 ml)
3. customThe organic phase is dried
4. customevaporated