Hydrochloric Acid → HCID 14724040, compound

Temperature

-78 °C

Methylacetoacetate (0.525 mL; 4.87 mmole) was added to a suspension of sodium hydride (0.160 g; 80% disp. in mineral oil) in THF at 0° C. and stirred for 10 minutes. N-Butyllithium (2.14 mL; 2.5M solution in hexanes) was added and reaction stirred for 15 minutes. This solution was added to a solution of the aldehyde (1.0 g; 3.2 mmole) (prepared in Example 124) in THF at 0° C. and stirred for 30 minutes. The reaction was treated with 2N HCl (30 mL) and extracted with EtOAc (3×15 mL). The organic layer was dried with MgSO4 and evaporated. The crude residue was triturated with hexane (3×25 mL) then dissolved in THF/CH3OH (4:1; 20 mL) and treated with triethylborane (3.2 mL; 1M solution in THF). Air was bubbled through the solution for 10 minutes and the reaction stirred for an additional 50 minutes. The solution was then cooled to -78° C. and treated with sodium borohydride (120 mg; 3.2 mmole) and stirred for 1 hour. The reaction was quenched with 2M HCl (100 mL) and extracted with EtOAc (3×20 mL). The organic layers were dried with MgSO4 and evaporated. The residue was dissolved in CH3OH (30 mL) and stirred for 15 hours. The solvent was evaporated and residue purified by chromatography using 50% EtOAc-hexane as eluent to afford the title compound as a yellow oil (470 mg; 33%). MS (CI): m/e=435 (M+H)+ ;

1. customreaction
2. stirringstirred for 15 minutes
3. stirringstirred for 30 minutes
4. extractionextracted with EtOAc (3×15 mL)
5. dry with materialThe organic layer was dried with MgSO4
6. customevaporated
7. customThe crude residue was triturated with hexane (3×25 mL)
8. dissolutionthen dissolved in THF/CH3OH (4:1; 20 mL)
9. additiontreated with triethylborane (3.2 mL; 1M solution in THF)
10. customAir was bubbled through the solution for 10 minutes
11. stirringthe reaction stirred for an additional 50 minutes
12. stirringstirred for 1 hour
13. customThe reaction was quenched with 2M HCl (100 mL)
14. extractionextracted with EtOAc (3×20 mL)
15. dry with materialThe organic layers were dried with MgSO4
16. customevaporated
17. dissolutionThe residue was dissolved in CH3OH (30 mL)
18. stirringstirred for 15 hours
19. customThe solvent was evaporated
20. customresidue purified by chromatography

ORD record

ord-076f264c7a534c689906e888593049d0

Source dataset

uspto-grants-1990_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04897490