反应详情

温度

0 °C

Boc-Ser-OtBu (200 mg, 0.77 mmol) was dissolved in 3 ml of methylene chloride and cooled to 0° C. N,N′-Carbonyldiimidazole (124 mg, 0.77 mmol) was added to the solution and stirred at room temperature for 2 hours. After the solvent was removed by distillation, 3-aminobenzenesulfonic acid (132.6 mg, 0.77 mmol), 2 ml of DMF and 0.4 ml of diisopropylethylamine were added and stirred at 70° C. overnight. The solvent was removed by distillation and the mixture was purified according to the purification step A to give the intermediate. The resulting intermediate was dissolved in 1 ml of TFA and stirred at room temperature for 2 hours. The solvent was removed by distillation, and the mixture was purified according to the purification step A to give the title compound.

1. additionwere added
2. stirringstirred at 70° C. overnight
3. customThe solvent was removed by distillation
4. customthe mixture was purified
5. customaccording to the purification step A
6. customto give the intermediate
7. stirringstirred at room temperature for 2 hours
8. customThe solvent was removed by distillation
9. customthe mixture was purified
10. customaccording to the purification step A