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HRID333877

反应详情

EQUATION

反应方程式

HRID 333877 的结构方程式

REACTANTS

反应物

3
结构：C1COCCN1
HCID8083

Morpholine

C4H9NO

结构：CCN=C=NCCCN(C)C.Cl
HCID2723939

1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride

C8H18ClN3

结构：NS(=O)(=O)c1ccc(N[C@@H](CSc2ccccc2)CC(=O)O)c([N+](=O)[O-])c1
HCID11683013

未命名化合物

PRODUCTS

生成物

1
结构：NS(=O)(=O)c1ccc(N[C@@H](CSc2ccccc2)CC(=O)N2CCOCC2)c([N+](=O)[O-])c1
HCID11591105

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

3
结构：CN(C)c1ccncc1
催化剂HCID14284

N,N-Dimethylpyridin-4-amine

C7H10N2

结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

结构：CCOC(C)=O
溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

To a mixture of Example 10D (0.75 g) and morpholine (0.318 g) in N,N-dimethylformamide (5 mL) were added N,N-dimethylpyridin-4-amine (0.445 g) and 1-ethyl-3-[3-(dimethylamino)propyl]-carbodiimide hydrochloride (0.699 g). The mixture was stirred overnight, diluted with ethyl acetate and washed with 5% aqueous HCl and water. The organic layer was dried over Na2SO4 and concentrated to give the title compound.

WORKUP

后处理

  1. washwashed with 5% aqueous HCl and water
  2. dry with materialThe organic layer was dried over Na2SO4
  3. concentrationconcentrated