反应详情

温度

160 °C

2-Bromobenzaldehyde (315 μL, 2.70 mmol), phenylboronic acid (395 mg, 3.24 mmol), Pd(PPh3)4 (31 mg, 0.027 mmol) and Na2CO3 (430 mg, 4.05 mmol) were dissolved in N,N-dimethylformamide (20 mL) in a reaction vessel and refluxed at 160° C. for 6 hours. After the reaction was completed, the reaction mixture was diluted with EtOAc and saturated NaHCO3 solution was added. The organic layer obtained by extracting the aqueous layer with EtOAc was dried with anhydrous MgSO4 and then filtered. The filtrate was concentrated under reduced pressure and the concentrate was purified by column chromatography (hexane:diethyl ether=8:1) to obtain 369 mg of the target compound (2.03 mmol, 75.0%).

1. additionwas added
2. customThe organic layer obtained
3. extractionby extracting the aqueous layer with EtOAc
4. dry with materialwas dried with anhydrous MgSO4
5. filtrationfiltered
6. concentrationThe filtrate was concentrated under reduced pressure
7. customthe concentrate was purified by column chromatography (hexane:diethyl ether=8:1)