反应详情

温度

25 °C

A mixture of thymine (7.68 g, 61 mmol), benzyl bromide (10.55 g, 61 mmol), potassium carbonate (17.05 g, 123 mmol) and DMF (90 mL) was stirred 12 hours at 25° C. The reaction mixture was poured into water (500 mL) and extracted with ethyl acetate (3×200 mL). The combined extract was washed with water (5×100 mL), dried (Na2SO4) and concentrated in vacuo. The residue was crystallized from hexane/ethyl acetate to give 1-benzyl-5-methyl-2,4(1H,3H)-pyrimidinedione (9.4 g, 43.9 mmol), m.p. 170°-173° C.

1. extractionextracted with ethyl acetate (3×200 mL)
2. extractionThe combined extract
3. washwas washed with water (5×100 mL)
4. dry with materialdried (Na2SO4)
5. concentrationconcentrated in vacuo
6. customThe residue was crystallized from hexane/ethyl acetate