Trifluoroacetic acid → HCID 21081510, compound

Temperature

0 °C

To 1-((4-(methylthio)pyrrolo[2,1-f][1,2,4]triazin-5-yl)methyl)piperidin-4-ol (188 mg, 0.675 mmol) in dichloromethane (7 mL) at 0° C. was added TFA (78 μL, 1.01 mmol) followed by m-CPBA (166 mg, 0.675 mmol, ˜70% pure). After stirring at 0° C. for 1 h, the mixture was concentrated in vacuo. Ether (20 mL) was added and then decanted off to remove the benzoic acid. The resulting crude sulfoxide was dried under high vacuum. 4-Amino-2-fluorophenol (343 mg, 2.7 mmol) was dissolved in THF (10 mL), cooled to −78° C., and charged with NaHMDS (2.7 mL, 2.7 mmol, 1 M in THF). After stirring at 0° C. for 5 min, the crude sulfoxide in THF (3 mL) was added. The reaction was stirred at 0° C. for 30 min and was then concentrated in vacuo. The residue was suspended in EtOAc (20 mL), washed with water (10 mL), dried over anhydrous sodium sulfate, and concentrated in vacuo. The crude product was purified by reverse phase prep HPLC and the appropriate fractions were concentrated in vacuo to remove methanol. The resulting aqueous solution was made basic with 5% aqueous sodium bicarbonate solution and extracted with EtOAc (3×10 mL). The combined extracts were dried over anhydrous sodium sulfate and concentrated in vacuo to give 36 mg (15%) of the title compound as a white solid. 1H NMR (DMSO-d6) δ 8.04 (s, 1H), 8.00 (d, 1H, J=2.8 Hz), 7.02 (t, 1H, J=8.8 Hz), 6.88 (d, 1H, J=2.8 Hz), 6.51 (dd, 1H, J=12.8, 2.8 Hz), 6.46–6.42 (m, 1H), 5.45 (br s, 2H), 3.83 (s, 2H), 3.18 (m, 1H), 2.76–2.71 (m, 2H), 2.12–2.06 (m, 2H), 1.72–1.67 (m, 2H), 1.41–1.38 (m, 2H); MS(ESI+) m/z 358.4 (M+H)+.

1. concentrationthe mixture was concentrated in vacuo
2. additionEther (20 mL) was added
3. customdecanted off
4. customto remove the benzoic acid
5. dry with materialThe resulting crude sulfoxide was dried under high vacuum
6. temperaturecooled to −78° C.
7. stirringAfter stirring at 0° C. for 5 min
8. stirringThe reaction was stirred at 0° C. for 30 min
9. concentrationwas then concentrated in vacuo
10. washwashed with water (10 mL)
11. dry with materialdried over anhydrous sodium sulfate
12. concentrationconcentrated in vacuo
13. customThe crude product was purified by reverse phase prep HPLC
14. concentrationthe appropriate fractions were concentrated in vacuo
15. customto remove methanol
16. extractionextracted with EtOAc (3×10 mL)
17. dry with materialThe combined extracts were dried over anhydrous sodium sulfate
18. concentrationconcentrated in vacuo

ORD record

ord-2eee81280105406bbda18fd0e9882db2

Source dataset

uspto-grants-2007_02

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07173031B2