反应详情

温度

80 °C

To a solution of 2-methylindole-4-carboxylic acid (690 mg; prepared in Reference Example 10) in N,N-dimethylformamide (10 ml) was added anhydrous potassium carbonate (815 mg) and benzyl bromide (0.7 ml) at room temperature, and the mixture was stirred at 80° C. for 2 hours. To the reaction solution was added water and ethyl acetate, and then extracted. The aqueous layer was extracted with ethyl acetate. The combined organic layer was washed with water and a saturated aqueous solution of sodium chloride, successively, dried and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (hexane—ethyl acetate) to give the title compound (610 mg) having the following physical data.

1. extractionextracted
2. extractionThe aqueous layer was extracted with ethyl acetate
3. washThe combined organic layer was washed with water
4. dry with materiala saturated aqueous solution of sodium chloride, successively, dried
5. concentrationconcentrated under reduced pressure
6. customThe residue was purified by column chromatography on silica gel (hexane—ethyl acetate)