反应详情

To a solution of 1-[(6-bromonaphthalen-2-yl)sulfonyl]-4-[4-(pyridin-4-yl)benzoyl]piperazine (310 mg) and triphenylphosphine (455 mg) in tetrahydrofuran (1.0 ml), triethylamine (3.0 ml), N,N-dimethylformamide (1.0 ml), trimethylsilylacetylene (130 ml) and palladium acetate (13.0 mg) were added, followed by heating under reflux for 2 hours. After the reaction mixture was allowed to cool down to room temperature, dichloromethane (15 ml) and water (30 ml) were added to separate the organic layer. The organic layer thus obtained was dried over anhydrous sodium sulfate and distilled under reduced pressure to remove the solvent. The residue was purified by chromatography on a silica gel column (dichloromethane:acetone=3:1), whereby colorless amorphous was obtained. The resulting product was dissolved in methanol (25 ml), followed by the addition of tetrahydrofuran (5.0 ml) and potassium carbonate (300 mg). The resulting mixture was stirred for 30 minutes. Dichloromethane (30 ml) and water (50 ml) were added to the reaction mixture to separate the organic layer. The organic layer thus obtained was dried over anhydrous sodium sulfate and distilled under reduced pressure to remove the solvent. The residue was purified by chromatography on a silica gel column (dichloromethane acetone=4:1), followed by pulverization and washing in a mixed solvent of dichloromethane, acetone and water, whereby the title compound (210 mg, 75%) was obtained.

1. temperatureby heating
2. temperatureunder reflux for 2 hours
3. customto separate the organic layer
4. customThe organic layer thus obtained
5. dry with materialwas dried over anhydrous sodium sulfate
6. distillationdistilled under reduced pressure
7. customto remove the solvent
8. customThe residue was purified by chromatography on a silica gel column (dichloromethane:acetone=3:1), whereby colorless amorphous
9. customwas obtained
10. customto separate the organic layer
11. customThe organic layer thus obtained
12. dry with materialwas dried over anhydrous sodium sulfate
13. distillationdistilled under reduced pressure
14. customto remove the solvent
15. customThe residue was purified by chromatography on a silica gel column (dichloromethane acetone=4:1)
16. washwashing in a mixed solvent of dichloromethane, acetone and water, whereby the title compound (210 mg, 75%)
17. customwas obtained