反应详情

A solution of 4,4′-dihydroxybiphenyl (3.72 g, 20 mmol), acrylic acid 6-iodohexyl ester (4.21 g, 15 mmol) and potassium carbonate (2.07 g, 15 mmol) in DMF (50 ml) was stirred overnight at room temperature and under argon atmosphere. The reaction mixture was then poured into HCl 3N (100 ml) and extracted with ether (3×200 ml). The combined organic extracts were washed with saturated NaCl solution (200 ml), dried over magnesium sulfate, filtered and evaporated to dryness. The crystalline residue obtained was purified on silica-gel column (CH2Cl2, CH2Cl2/Et2O:19/1). This gave acrylic acid 6-(4′-hydroxybiphen-4-yloxy-)hexyl ester as white crystalline material. Yield 2.5 g.

1. extractionextracted with ether (3×200 ml)
2. washThe combined organic extracts were washed with saturated NaCl solution (200 ml)
3. dry with materialdried over magnesium sulfate
4. filtrationfiltered
5. customevaporated to dryness
6. customThe crystalline residue obtained
7. customwas purified on silica-gel column (CH2Cl2, CH2Cl2/Et2O:19/1)