反应详情

温度

60 °C

A suspension of 6-(2-furyl)-2-oxo-1,2-dihydro-3-pyridinecarbonitrile (6.0 g, 32.3 mmol), 2-chloroacetamide (3.0 g, 37.7 mmol), sodium iodide (5.7 g, 38.0 mmol) and potassium carbonate (9.0 g, 56.2 mmol) in acetone (100 ml) was stirred at 60° C. for 6 hours. After cooling as it was, the reaction solution was diluted with ethyl acetate and water. The organic layer was washed with an aqueous saturated solution of sodium bicarbonate (×2) and an aqueous saturated solution of ammonium chloride, dried over anhydrous sodium sulfate, and concentrated. Diethyl ether was added to the residue, and the resulting precipitates were collected by filtration and washed with diethyl ether, to give the title compound (4.2 g, 54%) as a brown solid.

1. temperatureAfter cooling as it
2. washThe organic layer was washed with an aqueous saturated solution of sodium bicarbonate (×2)
3. dry with materialan aqueous saturated solution of ammonium chloride, dried over anhydrous sodium sulfate
4. concentrationconcentrated
5. additionDiethyl ether was added to the residue
6. customthe resulting precipitates
7. filtrationwere collected by filtration
8. washwashed with diethyl ether