Trifluoroacetic acid → HCID 86611300, compound

HRID 354449Notes

Reaction equation

HRID 354449 reaction equation
C(O[C:6]([N:8]1[CH2:12][C@H:11]([N:13]([CH3:20])[C:14](=[O:19])[C:15]([F:18])([F:17])[F:16])[CH2:10][C@H:9]1[CH2:21][O:22][C:23]1[CH:32]=[CH:31][C:26]([C:27]([O:29][CH3:30])=[O:28])=[CH:25][CH:24]=1)=[O:7])(C)(C)C.C(O)(C(F)(F)F)=[O:34].C1[CH:41]=[CH:42][C:43]2N(O)N=N[C:44]=2[CH:45]=1.C(N([CH2:55][CH3:56])CC)C.[CH3:57][CH2:58][N:59]=[C:60]=[N:61][CH2:62][CH2:63][CH2:64]N(C)C.Cl.C1[CH2:73][O:72][CH2:71][CH2:70]1>C(Cl)Cl.CC#N>[CH3:73][O:72][C:71]1[CH:70]=[C:55]([CH2:56][C:6]([N:8]2[CH2:12][C@H:11]([N:13]([CH3:20])[C:14](=[O:19])[C:15]([F:18])([F:16])[F:17])[CH2:10][C@H:9]2[CH2:21][O:22][C:23]2[CH:32]=[CH:31][C:26]([C:27]([O:29][CH3:30])=[O:28])=[CH:25][CH:24]=2)=[O:7])[CH:64]=[CH:63][C:62]=1[NH:61][C:60]([NH:59][C:58]1[CH:57]=[CH:45][CH:44]=[CH:43][C:42]=1[CH3:41])=[O:34]

Participants

9

Reactant 6

HCID 6422Trifluoroacetic acidHCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 757711-HydroxybenzotriazoleHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 20737852HCID 20737852, compound

Product 1

HCID 86611300HCID 86611300, compoundYield 82%

Reagents, catalysts & solvents 2

HCID 6342AcetonitrileSolventHCID 6344DichloromethaneSolvent

Procedure

To a stirred solution of methyl 4-[trans-1-tert-butoxycarbonyl-4-(N-methyl-trifluoro acetoamido)-(2S)-pyrrolidinyl]methoxybenzoate (390 mg, 0.85 mmol) in CH2Cl2 (8.0 ml) was added TFA (5.0 ml) at 0° C. The reaction mixture was stirred at room temperature for 0.5 hr. The mixture was concentrated in vacuo. Sat. NaHCO3 was added to the residue, and extracted with CH2Cl2. The extract was washed with brine, dried over Na2SO4, and concentrated in vacuo. The crude product was used to the subsequent reaction without further purification. To a stirred solution of the crude product, 3-methoxy-4-[N′-(2-methylphenyl)uredio]phenylacetic acid (279 mg, 0.89 mmol), HOBt (143 mg, 1.1 mmol), and triethylamine (246 ml, 1.77 mmol) in THF (8.0 ml) and MeCN (8.0 ml) was added EDC.HCl (255 mg, 1.3 mmol) at 0° C. The reaction mixture was stirred at room temperature for 16 hr, and concentrated in vacuo. Water was added to the residue, and extracted with EtOAc. The extract was washed with sat. NaHCO3, 2-M citric acid, and sat. NaHCO3, then dried over Na2SO4, and concentrated in vacuo. The residue was purified by column chromatography on silica gel with EtOAc-n-hexane (4:1, v/v) as eluent to give methyl 4-[trans-1-[3-methoxy-4-[N′-(2-methylphenyl)ureido]phenylacetyl]-4-(N-methyl-trifluoroacetoamido)-(2S) -pyrrolidinyl]methoxybenzoate (480 mg, 82%) as a colorless oil. 1H-NMR (CDCl3) δ2.18-2.35 (m, 2H), 2.31 (s, 3H), 2.87 and 2.97 (each s, total 3H), 3.45-3.46 (m, 3H), 3.47 (s, 3H), 3.49 (s, 2H), 3.88 (s, 3H), 4.30-4.70 (m, 2H), 5.20-5.40 (m, 1H), 6.38-6.43 (m, 1H), 6.67-6.86 (m, 4H), 7.09-724 (m, 4H), 7.51-7.54 (m, 1H), 7.93-8.08 (m, 3H).

Workup

  1. concentrationThe mixture was concentrated in vacuo
  2. additionSat. NaHCO3 was added to the residue
  3. extractionextracted with CH2Cl2
  4. washThe extract was washed with brine
  5. dry with materialdried over Na2SO4
  6. concentrationconcentrated in vacuo
  7. customThe crude product was used to the subsequent reaction without further purification
  8. stirringThe reaction mixture was stirred at room temperature for 16 hr
  9. concentrationconcentrated in vacuo
  10. additionWater was added to the residue
  11. extractionextracted with EtOAc
  12. washThe extract was washed with sat. NaHCO3, 2-M citric acid, and sat. NaHCO3
  13. dry with materialdried over Na2SO4
  14. concentrationconcentrated in vacuo
  15. customThe residue was purified by column chromatography on silica gel with EtOAc-n-hexane (4:1

Sources & evidence

ORD record
ord-c3041dc6b296450fa5ac82d422403cd2
Source dataset
uspto-grants-2004_06
Patent number
US06756378B2

Reaction notes

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