反应详情

13.2 g of trityl chloride were slowly added to a cooled mixture of 11 g of the product of Step C, 20 ml of dry dimethylformamide, 40 ml of methylene chloride and 6.2 ml of triethylamine and the mixture was stirred for 21/2 hours. 43 ml of N hydrochloric acid were added thereto and the mixture was stirred and decanted. The organic phase was washed with 40 ml of water and was extracted with methylene chloride. The extracts were dried and vacuum filtered. The filtrate was evaporated to dryness to obtain 27.7 g of ethyl 2-(2-tritylamino-4-thiazolyl)-2-(1-methylethoxyimino)-acetate in the syn configuration.

1. stirringthe mixture was stirred
2. customdecanted
3. washThe organic phase was washed with 40 ml of water
4. extractionwas extracted with methylene chloride
5. customThe extracts were dried
6. filtrationvacuum filtered
7. customThe filtrate was evaporated to dryness