1-Bromo-3-chloropropane → HCID 18940716, compound

HRID 355820Notes

Reaction equation

HRID 355820 reaction equation
[C:1]1([C:7]2[N:11]=[C:10]([C:12]3[N:13]=[CH:14][C:15]4[NH:16][C:17]5[C:22]([C:23]=4[CH:24]=3)=[CH:21][CH:20]=[CH:19][CH:18]=5)[O:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Br[CH2:26][CH2:27][CH2:28][Cl:29].[H-].[Na+]>CN(C=O)C>[Cl:29][CH2:28][CH2:27][CH2:26][N:16]1[C:15]2[CH:14]=[N:13][C:12]([C:10]3[O:9][N:8]=[C:7]([C:1]4[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=4)[N:11]=3)=[CH:24][C:23]=2[C:22]2[C:17]1=[CH:18][CH:19]=[CH:20][CH:21]=2

Participants

5

Reactant 3

HCID 80061-Bromo-3-chloropropaneHCID 24758Sodium hydrideHCID 18940731HCID 18940731, compound

Product 1

HCID 18940716HCID 18940716, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The compound was synthesized by mixing (Compound 8) (0.6 g, 1.9 mmol), 1-bromo-3-chloropropane (0.45 g, 2.9 mmol), NaH (0.09 g, 2.3 mmol) in DMF, in the same manner as illustrated in example 3 to give the title compound (0.72 g, 97%). M.p. 192°-195° C. (and 235.5°-236° C.).

Workup

  1. customThe compound was synthesized

Sources & evidence

ORD record
ord-fba097e91d5d4cc095bb706d2ed14a85
Source dataset
uspto-grants-1998_11
Patent number
US05834482

Reaction notes

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